Events at the MPIAB

Limits to viral evolution: insights from aquatic viruses

Biology seminar by Dr. Eva Lievens, Limnological Institute, AG Becks
Link to attend the seminars: https://tinyurl.com/2p86vusy [more]

Sustainability Group Meeting / Nachhaltigkeitstreffen MPIAB

Discuss with us how to make the MPI-AB more sustainable or send a mail to info.sustainability@ab.mpg.de! [more]

The neurobiology of zombie flies: mechanisms of parasite host-manipulation

For at least two centuries, scientists have been enthralled by the “zombie” behaviors induced by mind-controlling parasites. Despite this interest, the mechanistic bases of these uncanny processes have remained mostly a mystery. We leveraged the Entomophthora muscae-Drosophila melanogaster “zombie fly” system to reveal the molecular and cellular underpinnings of summit disease, a manipulated behavior evoked by many fungal parasites. Using high-throughput behavior assays to measure summiting, we discovered that summiting behavior is characterized by a burst of locomotion and requires the host circadian and neurosecretory systems, specifically DN1p circadian neurons, pars intercerebralis to corpora allata projecting (PI-CA) neurons and corpora allata (CA), the sole site of juvenile hormone (JH) synthesis and release. The blood-brain barrier of flies late in their infection was significantly permeabilized, suggesting that factors in the hemolymph may have greater access to the central nervous system during summiting. Metabolomic analysis of hemolymph from summiting flies revealed differential abundance of several compounds compared to non-summiting flies. Transfusing the hemolymph of summiting flies into non-summiting recipients induced a burst of locomotion, demonstrating that factor(s) in the hemolymph likely cause summiting behavior. Altogether, our work reveals a neuro-mechanistic model for summiting wherein fungal cells perturb the fly’s hemolymph, activating the neurohormonal pathway linking clock neurons to juvenile hormone production in the CA, ultimately inducing locomotor activity in their host. [more]

Ethical project design for research involving animals

Ethical awareness lies at the heart of any research-programme that involves using animals. While we tend to design a project and then consider the ethics, placing research ethics and animal welfare foremost in the development process does more than help to gain approval for the work; a clearly defined harm-benefit analysis can shape the project’s development, underpinning all aspects of the work, and identifying the research benefits from the beginning.In this workshop you will cover all aspects of ethical thinking covered by research regulations and FELASA requirements. You will understand the different attitudes to animals held by society, the core ideas that underpin perspectives and how they have influenced current legislation and practices. Considering ethics in practice does not provide the ‘truth’ but will help you understand the differences between views held by different members of society, and why those perspectives are important. This training uses ethical thinking as a foundation to create a protocol with clear outcomes, and with benefits that can be clearly understood by both those who assess its suitability and those who will work within it. You will learn how to write a clear harm-benefit statement and use it as the focus for a successful research application: one that is approved first time. [more]

Environmental genomics in past and present ecosystems

Biology seminar by Jun.-Prof. Laura Epp, Limnological Institute, Environmental Genomics
Link to attend the seminars: https://tinyurl.com/2p86vusy [more]

Institute Seminar by Franjo Weissing

Sustainability Group Meeting / Nachhaltigkeitstreffen MPIAB

Discuss with us how to make the MPI-AB more sustainable or send a mail to info.sustainability@ab.mpg.de! [more]

Institute Seminar by Gerit Linneweber

SARS-CoV-2 in Animals: What goes around …comes around

Institute Seminar by Jürgen Richt
In this presentation, our work assessing the susceptibility of different animal species such as cats, pigs, sheep, cattle and white-tailed deer to experimental SARS-CoV-2 infection will be summarized, and detailed descriptions of the clinical disease and transmissibility in these animal models will be provided. The results of these studies are critical: (i) for our understanding of the clinical course of SARS-CoV-2 in naturally and experimentally susceptible host species; (ii) for the development of preclinical COVID-19 animal models; and (iii) for risk assessment of SARS-CoV-2 infections in domestic and wild animals and the possible transmission to other animals and humans. In summary, a comprehensive understanding of animal susceptibility to SARS-CoV-2 is crucial to inform public health and agricultural systems, and to guide environmental policies. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease 2019 (COVID-19) and responsible for the current pandemic. The susceptibility of domestic and wild animal species to infection is a critical facet of the SARS-CoV-2 ecology, since reverse zoonotic spillover events resulting in SARS-CoV-2 outbreaks in animal populations could result in the establishment of new virus reservoirs. Adaptative virus mutations in new animal species could also complicate ongoing mitigation strategies to combat SARS-CoV-2. In addition, animal species susceptible to SARS-CoV-2 infection are essential as preclinical models for the development and efficacy testing of effective vaccines and therapeutics. [more]

Sustainability Group Meeting / Nachhaltigkeitstreffen MPIAB

Discuss with us how to make the MPI-AB more sustainable or send a mail to info.sustainability@ab.mpg.de! [more]

Institute Seminar by Jacob Höglund

The unsung hero: how granulocyte CEACAM3 protects us from infectious bacteria

Biology seminar by Prof. Christof R. Hauck, Cell Biology
Link to attend the seminars: https://tinyurl.com/2p86vusy [more]

Institute Seminar by Alice Auersperg

Join in-person or online on zoom! [more]

Collective behaviour and decision-making in active colloidal systems

Biology seminar by Prof. Clemens Bechinger, Department of Physics & Centre for the Advanced Study of Collective Behaviour
Link to attend the seminars: https://tinyurl.com/2p86vusy [more]

Sustainability Group Meeting / Nachhaltigkeitstreffen MPIAB

Discuss with us how to make the MPI-AB more sustainable or send a mail to info.sustainability@ab.mpg.de! [more]

Institute Seminar by Louise Riotte-Lambert

Molecular simulation methods to study interactions in protein and RNA systems

Biology seminar by Prof. Christine Peter, Department of Chemistry, Computational and Theoretical Chemistry
Link to attend the seminars: https://tinyurl.com/2p86vusy [more]

Institute Seminar by Miguel Aguilera

Best paper award (BPA) WS 22/23

Biology seminar by Prof. Martin Scheffner, Head of the Department of Biology
Link to attend the seminars: https://tinyurl.com/2p86vusy [more]
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